Harrison M W, Connell R S, Campbell J R, Webb M C
Ann Surg. 1977 Mar;185(3):311-7. doi: 10.1097/00000658-197703000-00011.
The effect of systemic hypoxemia and hypovolemia on pulmonary fine structure was studied and compared in 12 Labrador puppies 6 days to 3 weeks old. Central venous and arterial pressures were monitored and arterial pH, PCO2 and PO2 recorded serially. In 4 puppies lung biopsies were taken after a two hour period of breathing 7% oxygen. Four other puppies were made hypovolemic by acute hemorrhage of 50% of the calculated blood volume and lung biopsies taken after one hour. Four control puppies were maintained under anesthesia for two hours, breathing an atmosphere of 20% oxygen before lung biopsies were taken. Both hypoxemia and hypovolemia resulted in similar pulmonary ultrastructural changes. These changes which occurred more frequently in areas where the air spaces and blood vessels were expanded, were characterized by aggregation of platelets and leucocytes in the vascular space, focal endothelial cell disruption, interstitial edema and type I epithelial cell discontinuities with exudation of plasma into the alveolar air spaces.
对12只6日龄至3周龄的拉布拉多幼犬进行了研究，比较了全身性低氧血症和低血容量对肺细微结构的影响。监测中心静脉压和动脉压，并连续记录动脉血pH值、二氧化碳分压和氧分压。4只幼犬在呼吸7%氧气两小时后进行肺活检。另外4只幼犬通过急性出血使其血容量减少计算出血量的50%，一小时后进行肺活检。4只对照幼犬在麻醉下维持两小时，在进行肺活检前呼吸20%氧气的空气。低氧血症和低血容量均导致相似的肺超微结构变化。这些变化在气腔和血管扩张的区域更频繁发生，其特征是血管腔内血小板和白细胞聚集、局灶性内皮细胞破坏、间质水肿以及I型上皮细胞连续性中断，血浆渗入肺泡气腔。
