Zaridze D G, Arkadieva M A, Day N E, Duffy S W
Department of Epidemiology, Cancer Research Center RAMS, Moscow, Russian Federation.
Br J Cancer. 1993 Feb;67(2):347-50. doi: 10.1038/bjc.1993.63.
In a case-control study of second primary cancers in Moscow, there were 165 cases and 294 controls, matched for site of first primary, duration of follow-up since first primary and relapse history. Of the cases, 18 were of acute, non-lymphocytic leukaemia (ANLL), with 39 matched controls. Risk of ANLL was assessed with respect to chemotherapy for the first primary tumour. The chemotherapeutic agents investigated were nitrogen mustard, cyclophosphamide, procarbazine, doxorubicin, bleomycin, vinblastine, vincristine, prednisone and combinations. Increased risks were associated with use of nitrogen mustard (odds ratio = 9.94, not significant), doxorubicin (odds ratio = 11.25, 0.1 > P > 0.05) and vincristine (odds ratio = 26.57, P < 0.05). Despite the small number of cases and potential confounding by other agents, these findings, together with those of previous studies, suggest that some non-alkylating agents may predispose to second malignancies.
在一项针对莫斯科地区第二原发性癌症的病例对照研究中，有165例病例和294名对照，根据第一原发性癌症的部位、自第一原发性癌症起的随访时间以及复发史进行匹配。在这些病例中，有18例为急性非淋巴细胞白血病（ANLL），有39名匹配的对照。针对第一原发性肿瘤的化疗情况评估了ANLL的风险。所研究的化疗药物有氮芥、环磷酰胺、丙卡巴肼、阿霉素、博来霉素、长春花碱、长春新碱、泼尼松以及联合用药。使用氮芥（比值比=9.94，无显著性差异）、阿霉素（比值比=11.25，0.1＞P＞0.05）和长春新碱（比值比=26.57，P＜0.05）会增加风险。尽管病例数量较少且可能存在其他药物的混杂影响，但这些发现与先前研究的结果共同表明，一些非烷化剂可能会诱发第二原发性恶性肿瘤。
