CTR1是拟南芥乙烯反应途径的负调控因子，编码raf蛋白激酶家族的一个成员。
CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases.
作者信息
Kieber J J, Rothenberg M, Roman G, Feldmann K A, Ecker J R
机构信息
Department of Biology, University of Pennsylvania, Philadelphia 19104-6018.
出版信息
Cell. 1993 Feb 12;72(3):427-41. doi: 10.1016/0092-8674(93)90119-b.
PMID:8431946
Abstract
We isolated a recessive Arabidopsis mutant, ctr1, that constitutively exhibits seedling and adult phenotypes observed in plants treated with the plant hormone ethylene. The ctr1 adult morphology can be phenocopied by treatment of wild-type plants with exogenous ethylene and is due, at least in part, to inhibition of cell elongation. Seedlings and adult ctr1 plants show constitutive expression of ethylene-regulated genes. The epistasis of ctr1 and other ethylene response mutants has defined the position of CTR1 in the ethylene signal transduction pathway. The CTR1 gene has been cloned, and the DNA sequences of four mutant alleles were determined. The gene encodes a putative serine/threonine protein kinase that is most closely related to the Raf protein kinase family.
摘要
我们分离出了一个隐性拟南芥突变体ctr1，该突变体在幼苗期和成年期均表现出与用植物激素乙烯处理的植物中所观察到的表型。ctr1成年植株的形态可以通过用外源乙烯处理野生型植株来模拟，并且至少部分是由于细胞伸长受到抑制。ctr1幼苗和成年植株均表现出乙烯调控基因的组成型表达。ctr1与其他乙烯反应突变体的上位性确定了CTR1在乙烯信号转导途径中的位置。CTR1基因已被克隆，并测定了四个突变等位基因的DNA序列。该基因编码一种推定的丝氨酸/苏氨酸蛋白激酶，与Raf蛋白激酶家族关系最为密切。
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