Vargas F, Rivas C, Machado R, Sarabia Z, López I
Centro de Química, Instituto Venezolano de Investigaciones Científicas I.V.I.C., Caracas.
J Photochem Photobiol B. 1993 Jan;17(1):41-5. doi: 10.1016/1011-1344(93)85005-s.
Red blood cell lysis, photosensitized by the products of the aerobic photolysis of benzydamine (1) and azapropazone (4), was investigated. Irradiation of a methanol solution of 1 and 4 under oxygen produces the photoproducts 3-hydroxy-benzydamine, (2), 2-(3-dimethylaminopropyl)-1-benzylindazolin-3-one (3) and 3-dimethylamino-7-methyl-1,2,4-benzotriazine (5). The mechanism of the photodegradation of 1 was examined. Photoproducts 3 and 5 produce singlet oxygen as demonstrated by trapping with 2,5-dimethylfuran. The photohemolysis rate for the photoproducts 3 and 5 was enhanced by deuterium oxide and oxygen. No change was observed in the presence of reduced glutathione. The photohemolysis rate was low under anaerobic conditions.
研究了由苄达明（1）和阿扎丙宗（4）的需氧光解产物引发的红细胞裂解。在氧气存在下，对1和4的甲醇溶液进行辐照会产生光产物3-羟基苄达明（2）、2-（3-二甲基氨基丙基）-1-苄基吲唑啉-3-酮（3）和3-二甲基氨基-7-甲基-1,2,4-苯并三嗪（5）。对1的光降解机制进行了研究。通过用2,5-二甲基呋喃捕获证明，光产物3和5会产生单线态氧。重水和氧气可提高光产物3和5的光溶血速率。在存在还原型谷胱甘肽的情况下未观察到变化。在厌氧条件下，光溶血速率较低。
