Ho C W, Shioda K, Shirasaki K, Takahashi S, Tokimatsu S, Maeda K
Department of Pediatrics, Saitama Medical School, Japan.
J Pediatr Gastroenterol Nutr. 1993 Jan;16(1):53-60. doi: 10.1097/00005176-199301000-00011.
Specimens of the extrahepatic biliary trees and wedge liver biopsies were studied in 11 cases of biliary atresia. The hepatic arteries at the porta hepatis were examined with ultrasound in five of the 11 cases. The basic histopathological features were found to be epithelial damage and an inflammatory, sclerosing change of both the intrahepatic and the extrahepatic biliary trees, combined with an arteriopathy manifesting as hyperplasia and hypertrophy of the hepatic arteries in all cases. Based on the results of ultrasonography and histological examination, this arteriopathy was thought to affect the arteries from the trunk of the common hepatic artery to its peripheral branches supplying the entire biliary tree. To determine whether these morphologically abnormal hepatic arteries are related to the pathogenesis of biliary atresia in association with abnormal blood flow and pressure requires further investigation.
对11例胆道闭锁患者的肝外胆管标本和楔形肝活检组织进行了研究。11例患者中有5例在肝门处用超声检查了肝动脉。发现基本组织病理学特征为上皮损伤以及肝内和肝外胆管的炎症性硬化改变，并伴有动脉病变，表现为所有病例中肝动脉的增生和肥大。根据超声检查和组织学检查结果，认为这种动脉病变影响从肝总动脉主干到供应整个胆管树的外周分支的动脉。要确定这些形态异常的肝动脉是否与伴有异常血流和压力的胆道闭锁发病机制有关，还需要进一步研究。
