Department of pediatric intensive care unit, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Front Cell Infect Microbiol. 2024 Jul 22;14:1411843. doi: 10.3389/fcimb.2024.1411843. eCollection 2024.
Biliary atresia (BA) is a progressive fibroinflammatory disease affecting both the extrahepatic and intrahepatic bile ducts, potentially leading to chronic cholestasis and biliary cirrhosis. Despite its prevalence, the exact mechanisms behind BA development remain incompletely understood. Recent research suggests that the gut microbiota and its metabolites may play significant roles in BA development. This paper offers a comprehensive review of the changing characteristics of gut microbiota and their metabolites at different stages of BA in children. It discusses their influence on the host's inflammatory response, immune system, and bile acid metabolism. The review also explores the potential of gut microbiota and metabolites as a therapeutic target for BA, with interventions like butyrate and gut microbiota preparations showing promise in alleviating BA symptoms. While progress has been made, further research is necessary to untangle the complex interactions between gut microbiota and BA, paving the way for more effective prevention and treatment strategies for this challenging condition.
先天性胆道闭锁（BA）是一种影响肝内外胆管的进行性纤维炎症性疾病，可能导致慢性胆汁淤积和胆汁性肝硬化。尽管其发病率较高，但 BA 发展的确切机制仍不完全清楚。最近的研究表明，肠道微生物群及其代谢物可能在 BA 的发展中发挥重要作用。本文全面综述了儿童 BA 不同阶段肠道微生物群及其代谢物的变化特征。讨论了它们对宿主炎症反应、免疫系统和胆汁酸代谢的影响。本文还探讨了肠道微生物群及其代谢物作为 BA 治疗靶点的潜力，丁酸盐和肠道微生物群制剂等干预措施有望缓解 BA 症状。虽然已经取得了一些进展，但仍需要进一步研究来理清肠道微生物群与 BA 之间复杂的相互作用，为这种具有挑战性的疾病制定更有效的预防和治疗策略铺平道路。
