Namba T, Narumiya S
Department of Pharmacology, Faculty of Medicine, Kyoto University.
Nihon Rinsho. 1993 Jan;51(1):233-40.
Thromboxane A2 is an unstable, yet quite potent metabolite of arachidonic acid. Analysis of cDNAs of human and mouse thromboxane A2 receptors revealed important information in regard to the function of thromboxane A2 and its regulation. Examination of amino acid sequences of the receptors provides some information how the ligand binds to the receptor and how desensitization of the receptor occurs. mRNA of the thromboxane A2 receptor is abundantly expressed in the thymus, lung and spleen, and suggests novel function of thromboxane A2. Further progress on understanding of thromboxane A2 and development of effective drugs may be made on the basis of these findings.
血栓素A2是一种不稳定但相当强效的花生四烯酸代谢产物。对人和小鼠血栓素A2受体的cDNA分析揭示了有关血栓素A2功能及其调节的重要信息。对受体氨基酸序列的研究提供了一些关于配体如何与受体结合以及受体脱敏如何发生的信息。血栓素A2受体的mRNA在胸腺、肺和脾脏中大量表达，这提示了血栓素A2的新功能。基于这些发现，在对血栓素A2的理解以及有效药物的研发方面可能会取得进一步进展。
