Koike K, Fujimaki M
Department of Clinical Pathology, Tokyo Medical College.
Nihon Rinsho. 1993 Jan;51(1):37-42.
New assays for thrombin-antithrombin III complex, plasmin-alpha 2-plasmin inhibitor complex, FDP-D-dimer, t-PA/PAI-1 complex and prothrombin fragment F1+2 are reviewed as molecular markers for disseminated intravascular coagulation (DIC). These are sensitive to early stage indication of DIC. Fluctuation of their levels was also relative to the state of DIC. It is therefore believed that they will play an important role in the diagnosis of DIC, as solid members of its parameter. On the other hand, t-PA/PAI-1 complex is suggested to be the complication marker of DIC, such as multiple organ failure (MOF), as its level was thought to reflect endothelial cell stimulation during DIC.
作为弥散性血管内凝血（DIC）的分子标志物，对凝血酶 - 抗凝血酶III复合物、纤溶酶 - α2 - 纤溶酶抑制物复合物、FDP - D - 二聚体、组织型纤溶酶原激活物/纤溶酶原激活物抑制物 - 1复合物及凝血酶原片段F1 + 2的新检测方法进行了综述。这些方法对DIC的早期诊断很敏感。其水平的波动也与DIC的状态相关。因此，人们认为它们作为DIC参数的可靠组成部分，将在DIC的诊断中发挥重要作用。另一方面，由于组织型纤溶酶原激活物/纤溶酶原激活物抑制物 - 1复合物的水平被认为反映了DIC期间内皮细胞的激活情况，所以它被认为是DIC并发症（如多器官功能衰竭（MOF））的标志物。
