Lentz S R, Krewson L, Zutter M M
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Med Pediatr Oncol. 1993;21(2):137-41. doi: 10.1002/mpo.2950210211.
Neuroendocrine carcinoma of the skin, Merkel cell carcinoma, is an aggressive malignancy with a high incidence of local recurrence and metastasis. We describe a case of neuroendocrine carcinoma of the skin with unusual metastatic spread to the bone marrow in a 55-year-old man with systemic lupus erythematosus. Following resection of a left temporal subcutaneous nodule and complete left parotidectomy and radical lymph node dissection, the patient presented with pancytopenia. Although focal bony metastatic disease was not identified, his bone marrow was diffusely replaced by metastatic carcinoma. High-dose chemotherapy allowed a brief remission; however, the patient subsequently died with central nervous system metastases.
皮肤神经内分泌癌，即默克尔细胞癌，是一种侵袭性恶性肿瘤，局部复发和转移发生率高。我们描述了一例皮肤神经内分泌癌病例，该病例发生在一名患有系统性红斑狼疮的55岁男性身上，出现了罕见的骨髓转移。在切除左颞部皮下结节、行左侧腮腺全切术及根治性淋巴结清扫术后，患者出现全血细胞减少。尽管未发现局灶性骨转移疾病，但他的骨髓被转移性癌广泛取代。大剂量化疗使病情短暂缓解；然而，患者随后死于中枢神经系统转移。
