Queirolo P, Gipponi M, Peressini A, Disomma C F, Vecchio S, Raposio E, Guenzi M, Sertoli M R, Cafiero E
Department of Medical Oncology, University of Genoa, Italy.
Anticancer Res. 1997 Jan-Feb;17(1B):673-7.
The clinical features of 10 cases with the adjunct of a literature review of primary neuroendocrine carcinoma of the skin (Merkel cell tumor) are reported. This cancer arises in the dermis and subcutaneous tissue of elderly individuals. Natural history is characterized by local recurrences (40%), regional lymph-nodes metastases (50%), and distant metastases (60%). Surgery is the elective treatment of primary and locoregional disease and subsequent radiotherapy prevents local recurrences and prolong disease-free survival in literature reports. Chemotherapy and radiotherary resulted in only a short-term palliative response in the metastatic setting.
报告了10例皮肤原发性神经内分泌癌（默克尔细胞肿瘤）的临床特征，并附加文献综述。这种癌症发生在老年人的真皮和皮下组织中。其自然病史的特点是局部复发（40%）、区域淋巴结转移（50%）和远处转移（60%）。在文献报道中，手术是原发性和局部区域疾病的首选治疗方法，随后的放疗可预防局部复发并延长无病生存期。在转移性情况下，化疗和放疗仅产生短期姑息性反应。
