使用含有芳香族结合裂缝的合成主体的化学键合固定相：硝基取代多环芳烃的高效液相色谱分析。
Chemically bonded stationary phases that use synthetic hosts containing aromatic binding clefts: HPLC analysis of nitro-substituted polycyclic aromatic hydrocarbons.
作者信息
Zimmerman S C, Saionz K W, Zeng Z
机构信息
Department of Chemistry, University of Illinois, Urbana 61801.
出版信息
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1190-3. doi: 10.1073/pnas.90.4.1190.
Abstract
The synthesis of hosts with improved binding affinities for nitroaromatic guests is described. Association constants for several host-guest complexes were measured in chloroform solution and ranged over three orders of magnitude. Two hosts were covalently linked to silica gel to produce chemically bonded stationary phases for HPLC. The use of these phases for HPLC analysis of nitro-substituted polycyclic aromatic hydrocarbons is discussed.
摘要
本文描述了对硝基芳烃客体具有更高结合亲和力的主体的合成。在氯仿溶液中测量了几种主体 - 客体配合物的缔合常数，其范围跨越三个数量级。将两种主体共价连接到硅胶上，以制备用于高效液相色谱（HPLC）的化学键合固定相。讨论了这些固定相在硝基取代的多环芳烃HPLC分析中的应用。
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