[甘露醇和地塞米松在感染性急性脑水肿治疗中的应用]
[Use of mannitol and dexamethasone in the management of acute cerebral edema of infectious origin].
作者信息
Sánchez R, Brindis L C, Fierro H, Strecker C, Muñoz O
出版信息
Bol Med Hosp Infant Mex. 1977 Mar-Apr;34(2):283-90.
The study included 22 patients with meningoencephalitis and hypertensive cranial syndrome from cerebral edema. Mannitol was given to 13 cases and dexamethasone to 9. There were three therapeutic failures in the group given mannitol and none in that of dexamethasone (p greater than 0.05). Both drugs showed similar effect in the duration of the hypertensive cranial syndrome (39-44 hrs). Patients treated with mannitol showed hyponatremia after 48 hours. No untoward effects appeared in patients given dexamethasone.
该研究纳入了22例患有脑膜脑炎和因脑水肿导致的高血压性颅脑综合征的患者。13例患者使用了甘露醇，9例使用了地塞米松。使用甘露醇的组中有3例治疗失败，而使用地塞米松的组中无治疗失败病例（p>0.05）。两种药物在高血压性颅脑综合征的持续时间（39 - 44小时）方面显示出相似的效果。使用甘露醇治疗的患者在48小时后出现低钠血症。使用地塞米松的患者未出现不良反应。
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