Barry M A, Larson D C, Frank M E
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030-3705.
Physiol Behav. 1993 Jan;53(1):75-80. doi: 10.1016/0031-9384(93)90013-6.
The ability of the gustatory system to recover following peripheral nerve injury was investigated in adult hamsters. A conditioned taste aversion paradigm was utilized to test sodium salt-taste function after bilateral crush of the chorda tympani nerve and after nerve regeneration. Bilateral chorda tympani crush abolished expression of a previously learned conditioned taste aversion to 0.1 M NaCl. At 10 to 16 weeks following surgery, the hamsters were reconditioned three times to 0.1 M NaCl. The hamsters were able to relearn the conditioned taste aversion and by 16 weeks, the crush and sham groups showed equally strong and specific aversions to 0.1 M NaCl. A second surgery to cut the regenerated chorda tympani nerves resulted, again, in the loss of expression of the conditioned taste aversion. Thus, regenerated chorda tympani nerves are capable of carrying the information needed to form a conditioned taste aversion specific for sodium salts in the adult hamster.
研究了成年仓鼠味觉系统在周围神经损伤后恢复的能力。采用条件性味觉厌恶范式，在双侧鼓索神经挤压后及神经再生后测试钠盐味觉功能。双侧鼓索神经挤压消除了先前习得的对0.1M NaCl的条件性味觉厌恶的表现。在手术后10至16周，仓鼠被三次重新适应0.1M NaCl。仓鼠能够重新学习条件性味觉厌恶，到16周时，挤压组和假手术组对0.1M NaCl表现出同样强烈且特异性的厌恶。第二次手术切断再生的鼓索神经，再次导致条件性味觉厌恶表现的丧失。因此，再生的鼓索神经能够携带形成成年仓鼠对钠盐特异性条件性味觉厌恶所需的信息。
