Chambers J P, Livingston A, Waterman A E, Goodship A E
Department of Pharmacology, Veterinary Surgery and Anatomy, University of Bristol.
Res Vet Sci. 1993 Jan;54(1):52-6. doi: 10.1016/0034-5288(93)90010-d.
This study was undertaken to assess the analgesia provided by detomidine (20 micrograms kg-1 intravenously) in thoroughbred horses. Pain thresholds to a mechanical noxious stimulus were measured before and after a period of mild chronic pain in one foreleg. Detomidine was a good analgesic in control animals; their pain thresholds were significantly elevated for about 60 minutes. After injury, the injured leg had a significantly lower pain threshold and the intensity and duration of analgesia provided by detomidine were significantly reduced. The analgesia in the opposite (sound) leg was also reduced, indicating that there were both central and peripheral aspects to this increased sensitivity to painful stimuli. Detomidine deserves to be considered as a potent analgesic in the horse rather than a sedative with analgesic side effects.
本研究旨在评估右美托咪定（20微克/千克静脉注射）对纯种马的镇痛效果。在一条前腿经历一段轻度慢性疼痛前后，测量对机械性有害刺激的疼痛阈值。右美托咪定对对照动物是一种良好的镇痛药；它们的疼痛阈值显著提高约60分钟。受伤后，受伤腿的疼痛阈值显著降低，右美托咪定提供的镇痛强度和持续时间显著缩短。对侧（未受伤）腿的镇痛效果也降低，表明对疼痛刺激的这种敏感性增加存在中枢和外周两方面的因素。右美托咪定应被视为马的强效镇痛药，而非具有镇痛副作用的镇静剂。
