Daniel T O, Kumjian D A
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Semin Nephrol. 1993 Jan;13(1):87-95.
In aggregate, the evidence reviewed here supports a very important role for PDGF expression and action at local glomerular and interstitial sites in human kidney development and disease. PDGF delivered by platelets, or produced by endogenous cells of the kidney is capable of stimulating responses including proliferation, matrix deposition, chemotaxis, and contraction in renal cells, particularly mesangial cells and interstitial fibroblasts. During kidney development, PDGF may mediate processes of cellular recruitment, extracellular matrix deposition, and proliferation with the constructive outcome of glomerulogenesis and vascularization. Proliferation and production of extracellular matrix components by these cells likely contribute to destructive proliferative and sclerotic responses attending proliferative and other glomerulopathies. As additional information accumulates, therapeutic targets within the PDGF system may provide opportunities to arrest destructive renal processes.
总体而言，本文综述的证据支持血小板衍生生长因子（PDGF）在人肾脏发育和疾病中的局部肾小球及间质部位的表达和作用具有非常重要的意义。由血小板释放或由肾脏内源性细胞产生的PDGF能够刺激包括肾脏细胞（特别是系膜细胞和间质成纤维细胞）的增殖、基质沉积、趋化性和收缩等反应。在肾脏发育过程中，PDGF可能介导细胞募集、细胞外基质沉积和增殖过程，从而产生肾小球发生和血管形成的建设性结果。这些细胞的增殖和细胞外基质成分的产生可能导致增殖性及其他肾小球病所伴随的破坏性增殖和硬化反应。随着更多信息的积累，PDGF系统内的治疗靶点可能为阻止肾脏破坏性进程提供机会。
