Floege J, Johnson R J
Division of Nephrology, Medizinische Hochschule Hannover, Germany.
Miner Electrolyte Metab. 1995;21(4-5):271-82.
Platelet-derived growth factor (PDGF) is a pleiotropic cytokine, that is synthesized by various resident renal cells and also by infiltrating cells. The best established role for PDGF in the kidney is the mediation of glomerular mesangial cell proliferation. There is also evidence to suggest an involvement of PDGF in the regulation of renal extracellular matrix turnover, the chemoattraction of mesangial cells and/or other cells to sites of injury, the regulation of glomerular hemodynamics, and lipoprotein uptake in the glomerulus. The first studies investigating the efficacy of anti-PDGF therapy in glomerular disorders point to a potentially novel approach to treat progressive renal disease.
血小板衍生生长因子（PDGF）是一种多效性细胞因子，由各种驻留肾细胞以及浸润细胞合成。PDGF在肾脏中最明确的作用是介导肾小球系膜细胞增殖。也有证据表明PDGF参与肾细胞外基质周转的调节、系膜细胞和/或其他细胞向损伤部位的化学趋化作用、肾小球血流动力学的调节以及肾小球中脂蛋白的摄取。最早研究抗PDGF疗法在肾小球疾病中疗效的研究指出了一种治疗进行性肾病的潜在新方法。
