Stanley C, Wolf P, Haghighi P
Department of Pathology, Veterans Administration Medical Center, San Diego, California.
Acta Cytol. 1993 Jan-Feb;37(1):90-2.
A patient with stage IV Hodgkin's disease developed severe dyspnea and was found to have pulmonary infiltrates one year following his initial diagnosis of nodular sclerosing Hodgkin's disease, stage IIB. Two separate cell block sputum cytology samples demonstrated Reed-Sternberg cells. The patient died of respiratory failure. At autopsy the main findings were extensive confluent nodules of Hodgkin's disease nearly replacing the pulmonary parenchyma of both lungs. Cytology of sputum or bronchial washings may reveal diagnostic Reed-Sternberg cells and establish the diagnosis of pulmonary Hodgkin's disease without a lung biopsy.
一名IV期霍奇金病患者在最初被诊断为IIB期结节硬化型霍奇金病一年后出现严重呼吸困难，发现有肺部浸润。两份独立的细胞块痰细胞学样本显示有里德-施特恩伯格细胞。该患者死于呼吸衰竭。尸检主要发现为广泛融合的霍奇金病结节，几乎取代了双肺的肺实质。痰液或支气管灌洗的细胞学检查可能会发现具有诊断意义的里德-施特恩伯格细胞，从而在不进行肺活检的情况下确诊肺霍奇金病。
