Gilchrist A B, Leake A, Charlton B G
Department of Anatomy, Glasgow University, Scotland.
Acta Anat (Basel). 1993;146(1):31-5. doi: 10.1159/000147417.
The inter-relationship between putative cholinergic and noradrenergic innervation of the human adrenal cortex was investigated using a technique which combined acetylcholinesterase histochemistry, choline acetyltransferase radiochemistry and dopamine beta-hydroxylase immunohistochemistry. Cholinergic and noradrenergic nerve fibres had a near-identical distribution, with varicose noradrenergic fibres located immediately alongside non-varicose cholinergic nerve bundles in all cortical zones. Choline acetyltransferase activity was consistently detected in the adrenal cortex, confirming the presence of cholinergic neurons. It is postulated that noradrenergic innervation has a role in the modulation of cortical endocrine secretion, while cholinergic nerves are mainly concerned with the control of medullary secretion.
利用一种结合乙酰胆碱酯酶组织化学、胆碱乙酰转移酶放射化学和多巴胺β-羟化酶免疫组织化学的技术，研究了人类肾上腺皮质假定的胆碱能和去甲肾上腺素能神经支配之间的相互关系。胆碱能和去甲肾上腺素能神经纤维分布几乎相同，在所有皮质区，曲张的去甲肾上腺素能纤维紧邻无曲张的胆碱能神经束。在肾上腺皮质中持续检测到胆碱乙酰转移酶活性，证实了胆碱能神经元的存在。据推测，去甲肾上腺素能神经支配在调节皮质内分泌分泌中起作用，而胆碱能神经主要与髓质分泌的控制有关。
