Fernández J G, Droz P O, Humbert B E, Caperos J R
Br J Ind Med. 1977 Feb;34(1):43-55. doi: 10.1136/oem.34.1.43.
The absorption, distribution, and excretion of trichloroethylene, as well as the kinetics of formation and elimination of trichloroethanol (TCE) and trichloroacetic acid (TCA) were simulated by a mathematical model. The results of this model have been satisfactorily compared with those obtained experimentally from pulmonary elimination of the solvent and from urinary excretion of the metabolites. The model permitted a study of the distribution of the solvent in the different tissues of the organism as well as an evaluation of the body burden of TCE and TCA. The influence of the duration and repetition of the exposure on the urinary eliminations of TCE and TCA was studied, and showed that the excretion of the first metabolite represents the most recent exposure while that of the second is related to the average exposure of the preceding days. The study of the pulmonary elimination of trichloroethylene during single or repeated exposures showed a linear relationship between the alveolar concentration of the solvent approximately 15 hours after the end of the exposure and the quantity of trichloroethylene accumulated in the fatty tissues.
用一个数学模型模拟了三氯乙烯的吸收、分布和排泄，以及三氯乙醇（TCE）和三氯乙酸（TCA）的形成和消除动力学。该模型的结果已与通过溶剂肺部消除和代谢产物尿排泄实验获得的结果进行了令人满意的比较。该模型允许研究溶剂在生物体不同组织中的分布，以及评估TCE和TCA的体内负荷。研究了暴露持续时间和重复次数对TCE和TCA尿排泄的影响，结果表明，第一种代谢产物的排泄代表最近的暴露，而第二种代谢产物的排泄与前几天的平均暴露有关。对单次或重复暴露期间三氯乙烯肺部消除的研究表明，暴露结束约15小时后，溶剂的肺泡浓度与脂肪组织中积累的三氯乙烯量之间存在线性关系。
