Narula A A, Sheppard I J, West K, Bradley P J
Department of Otolaryngology and Pathology, Leicester Royal Infirmary, UK.
Am J Otolaryngol. 1993 Jan-Feb;14(1):21-3. doi: 10.1016/0196-0709(93)90005-r.
Patients who present with airway obstruction due to carcinoma of the larynx may be managed by tracheotomy followed by definitive tumor surgery at a later date. An alternative is emergency laryngectomy, defined as total laryngectomy performed within 24 hours, for a previously untreated and undiagnosed malignancy. In this study, we compare and contrast the outcome of 13 patients managed by tracheotomy and delayed laryngectomy to another group of patients, previously reported, managed by emergency laryngectomy.
Stridor due to malignant laryngeal neoplasm was treated by tracheotomy and delayed definitive laryngectomy in 13 patients. In every case, the tracheostomy site was removed with a surgical specimen. A comparison of the survival data was performed with earlier reported series of 13 emergency laryngectomies using the Wilcoxon log rank method.
All patients were followed for a minimum of 24 months. Seven patients underwent postoperative radiotherapy. Two of these patients (15%) developed peristomal recurrence at 6 and 22 months respectively. Both died of disease. Six patients from each group survived disease free for a minimum of 24 months. No significant correlation was found between the time delay of definitive surgery and survival (P > .5).
This series suggests that emergency laryngectomy offers patients no survival advantage. Emergency laryngectomy does, however, have several disadvantages. These include the necessity to rely on frozen section analysis, the difficulty in obtaining expert anesthetic support, and the inability to provide thorough and complete nutritional and metabolic work up before major surgery. Finally, the psychologic aspects of radical surgery for patient and family cannot be adequately addressed. We conclude that stomal recurrence is as much a function of extensive disease at presentation as of preliminary tracheotomy. Emergency laryngectomy is not a superior treatment modality and offers no particular survival advantage.
因喉癌导致气道阻塞的患者可先进行气管切开术,随后在晚些时候进行确定性肿瘤手术。另一种选择是急诊喉切除术,即对先前未经治疗和诊断的恶性肿瘤在24小时内进行全喉切除术。在本研究中,我们将13例接受气管切开术和延迟喉切除术治疗的患者的结果与另一组先前报道的接受急诊喉切除术治疗的患者进行比较和对比。
13例因恶性喉肿瘤导致喘鸣的患者接受了气管切开术和延迟确定性喉切除术。在每例手术中,气管造口部位均与手术标本一并切除。使用Wilcoxon对数秩检验方法,将生存数据与先前报道的13例急诊喉切除术系列进行比较。
所有患者均至少随访24个月。7例患者接受了术后放疗。其中2例患者(15%)分别在6个月和22个月时出现造口周围复发。两人均死于疾病。每组各有6例患者无病生存至少24个月。未发现确定性手术的时间延迟与生存之间存在显著相关性(P>.5)。
本系列研究表明,急诊喉切除术对患者并无生存优势。然而,急诊喉切除术确实存在几个缺点。这些缺点包括需要依赖冰冻切片分析来确诊,难以获得专业的麻醉支持,以及在大手术前无法提供全面和完整的营养及代谢检查。最后,对于患者及其家属而言,根治性手术的心理影响也无法得到充分解决。我们得出结论,造口复发与就诊时疾病的广泛性以及初步气管切开术的关系同样密切。急诊喉切除术并非一种更优的治疗方式,也没有特别的生存优势。