Neuhaus O W, Flory W
Nephron. 1978;22(4-6):570-6. doi: 10.1159/000181537.
The excretion of total urinary proteins (TUP) of rats beginning at weaning and extending to 12 months of age was correlated with the output of the sex-dependent alpha2u-globulin and albumin. At puberty, 40 days of age, the excretion of TUP corresponded to the output of alpha2u-globulin. At this age, alpha2u represented 30% of the total while albumin less than 10%. From 100 to 200 days of age, TUP remained constant while the excretion of albumin steadily increased. After 150--180 days of age, the concentrations of alpha2u and albumin in TUP were approximately equal. Thereafter, the excretion of albumin and TUP increased markedly whereas alpha2u excretion remained constant. At 373 days of age, albumin represented over 50--60% of the TUP while alpha2u was only 6--7%. Female rats which excrete little or no alpha2u exhibited a much lower level of proteinuria than the male during the first year. We suggest the existence of two phases of proteinuria in the male rat, namely, an early physiologic or alpha2u-globulinuric phase and a later albuminuric phase during which increasing quantities of plasma proteins, especially albumin, are lost.
从断奶开始至12月龄大鼠的总尿蛋白（TUP）排泄量与性别依赖性α2u球蛋白和白蛋白的排出量相关。在青春期（40日龄），TUP的排泄量与α2u球蛋白的排出量相对应。此时，α2u占总量的30%，而白蛋白少于10%。在100至200日龄期间，TUP保持恒定，而白蛋白的排泄量稳步增加。在150 - 180日龄之后，TUP中α2u和白蛋白的浓度大致相等。此后，白蛋白和TUP的排泄量显著增加，而α2u的排泄量保持恒定。在373日龄时，白蛋白占TUP的50 - 60%以上，而α2u仅占6 - 7%。在第一年中，排泄少量或不排泄α2u的雌性大鼠蛋白尿水平远低于雄性大鼠。我们认为雄性大鼠存在两个蛋白尿阶段，即早期生理性或α2u球蛋白尿阶段以及后期白蛋白尿阶段，在此期间血浆蛋白尤其是白蛋白的丢失量不断增加。
