Correia O, Chosidow O, Saiag P, Bastuji-Garin S, Revuz J, Roujeau J C
Department of Dermatology, Hôpital Henri-Mondor, Université Paris-XII, Créteil, France.
Dermatology. 1993;186(1):32-7. doi: 10.1159/000247299.
A series of 90 consecutive cases of toxic epidermal necrolysis (TEN) observed in a single center between 1985 and March 1991 was compared to a previous series from the same institution in order to look for changes in the characteristics of the patients and in the drug etiology. The most salient change was the high prevalence of human immunodeficiency virus (HIV) infection among patients with TEN (20/90). This high rate of HIV infection was linked to two other changes: higher number of male patients leading to an equilibrated sex ratio and an increased role of sulfonamides-mainly sulfadiazine-as etiologic agents.
为了探寻患者特征及药物病因学的变化，我们将1985年至1991年3月期间在单一中心观察到的90例连续性中毒性表皮坏死松解症（TEN）病例，与同一机构之前的病例系列进行了比较。最显著的变化是TEN患者中人类免疫缺陷病毒（HIV）感染的高患病率（20/90）。这种高HIV感染率与另外两个变化有关：男性患者数量增加导致性别比例平衡，以及磺胺类药物（主要是磺胺嘧啶）作为病因的作用增加。
