Saiag P, Caumes E, Chosidow O, Revuz J, Roujeau J C
Departement de Dermatologie, Université Paris XII, Hôpital Henri Mondor, France.
J Am Acad Dermatol. 1992 Apr;26(4):567-74. doi: 10.1016/0190-9622(92)70082-q.
Although patients infected with the human immunodeficiency virus (HIV) are predisposed to cutaneous adverse drug reactions, only a few cases of toxic epidermal necrolysis (TEN) have been reported in this setting.
Our purpose was to examine the features of TEN in HIV-infected patients.
We performed a retrospective analysis of all HIV-infected patients in a series of 80 consecutive cases of TEN during a 6-year period.
Fourteen patients were HIV infected. They had typical TEN, with epidermal detachment involving 20.6% +/- 8.0% of the skin surface. Suspected drugs were sulfadiazine, trimethoprim-sulfamethoxazole, sulfadoxine, clindamycin, phenobarbital, and chlormezanone. Patients with the acquired immunodeficiency syndrome (AIDS) exhibit a dramatically increased risk of TEN. During our study period 15 cases of AIDS-associated TEN occurred in the greater Paris area, whereas 0.04 case would have been expected if the incidence of TEN were the same in these patients as in the general population.
HIV-infected patients, especially those with AIDS, may develop TEN that shares many similarities with the disease in immunocompetent patients.
尽管感染人类免疫缺陷病毒（HIV）的患者易发生皮肤药物不良反应，但在这种情况下仅报告了少数几例中毒性表皮坏死松解症（TEN）。
我们的目的是研究HIV感染患者中TEN的特征。
我们对6年期间连续80例TEN患者中的所有HIV感染患者进行了回顾性分析。
14例患者感染了HIV。他们患有典型的TEN，表皮剥脱面积占皮肤表面积的20.6%±8.0%。可疑药物为磺胺嘧啶、甲氧苄啶-磺胺甲恶唑、周效磺胺、克林霉素、苯巴比妥和氯美扎酮。获得性免疫缺陷综合征（AIDS）患者发生TEN的风险显著增加。在我们的研究期间，大巴黎地区发生了15例与AIDS相关的TEN，而如果这些患者中TEN的发病率与普通人群相同，预计只会有0.04例。
HIV感染患者，尤其是AIDS患者，可能发生与免疫功能正常患者的疾病有许多相似之处的TEN。
