Kappos A D, Schmitt O A
Behörde für Arbeit, Gesundheit und Soziales der Freien und Hansestadt Hamburg.
Gesundheitswesen. 1993 Jan;55(1):40-5.
The Conference of Ministers for the Environment commissioned a working group of the Länder Committee for Immission Protection to develop a concept of guidelines for the concentration of carcinogenic pollutants in the atmospheric aerosol. Of the large number of substances which have been identified as carcinogenic, seven were selected (arsenic, asbestos, benzene, cadmium, diesel exhaust, polynuclear aromatic hydrocarbons and 2,3,7,8-tetrachlorodibenzo-(p)-dioxin). These substances are emitted into the environment by amounts that are quantitatively of special importance for immission control. There are standardised measuring procedures for controlling them and their toxicological data base permits a quantitative assessment of cancer risk. The quantitative risk assessment by the working group was based on the WHO's "unit risk" model. It was decided that for evolving the guidelines the total cancer risk for all carcinogenic air pollutants be limited while at the same time the possible risk attributed to each individual substance should be reduced according to its contribution to the actual total cancer risk. The synthetic model developed by the working group is explained in detail and the resulting guidelines for an acceptable total cancer risk of 1:1000, 1:2500 und 1:5000 are stated.
环境部长会议委托联邦州排放保护委员会的一个工作组制定大气气溶胶中致癌污染物浓度的指导方针概念。在已被确定为致癌的大量物质中,选择了七种(砷、石棉、苯、镉、柴油废气、多环芳烃和2,3,7,8-四氯二苯并对二恶英)。这些物质向环境中的排放量在数量上对排放控制具有特殊重要性。有用于控制它们的标准化测量程序,并且它们的毒理学数据库允许对癌症风险进行定量评估。工作组的定量风险评估基于世界卫生组织的“单位风险”模型。决定在制定指导方针时,限制所有致癌空气污染物的总癌症风险,同时应根据每种物质对实际总癌症风险的贡献降低其可能的风险。详细解释了工作组开发的综合模型,并说明了得出的可接受总癌症风险为1:1000、1:2500和1:5000的指导方针。