Krishna D, Reddy P J
Indian Institute of Chemical Technology, Hyderabad.
Comput Appl Biosci. 1993 Feb;9(1):29-35. doi: 10.1093/bioinformatics/9.1.29.
The probit analysis model is generally used for the determination of lethal dosages in bioassay applications. However, the logit models, which use the logistic curve instead of the integrated normal curve, could also be effectively used for the determination of lethal dosages and regression coefficients. In this paper, two types of logit models, namely minimum logit chi square and maximum likelihood, have been described in detail for the estimation of the parameters. The results of these two models are also compared with those of the probit model.
概率单位分析模型通常用于生物测定应用中致死剂量的测定。然而,使用逻辑曲线而非正态积分曲线的逻辑回归模型也可有效地用于致死剂量和回归系数的测定。本文详细描述了两种逻辑回归模型,即最小卡方逻辑回归和最大似然法,用于参数估计。还将这两种模型的结果与概率单位模型的结果进行了比较。