Grönroos M, Salmi T A, Vuento M H, Jalava E A, Tyrkkö J E, Maatela J I, Aromaa A R, Siegberg R, Savolainen E R, Kauraniemi T V
Department of Obstetrics & Gynecology, University of Turku, Finland.
Cancer. 1993 Feb 15;71(4):1279-82. doi: 10.1002/1097-0142(19930215)71:4<1279::aid-cncr2820710418>3.0.co;2-4.
The interest in mass screening programs for the early detection of endometrial cancer (EC) has grown with the rising incidence of this disease. Preliminary programs directed at asymptomatic women with only one risk factor, i.e. age, have not been cost-effective.
In the current study, 597 asymptomatic women from 45-69 years of age with diabetes and/or hypertension were screened by Vabra (Berkeley Medevices Inc., Berkeley, CA) aspiration.
Among the women with diabetes, 6.3% preinvasive lesions of the endometrium were found. This is significantly more than the rate among women with hypertension, which was 1.3% (P < 0.01).
Regular mass screening programs for the early detection of EC should be directed at asymptomatic diabetic women 45 years of age or older. This study does not indicate that similar screenings would be effective for women with hypertension.
随着子宫内膜癌（EC）发病率的上升，对其早期检测的大规模筛查项目的关注度不断提高。针对仅有一个风险因素（即年龄）的无症状女性的初步筛查项目并不具有成本效益。
在本研究中，对597名年龄在45 - 69岁之间患有糖尿病和/或高血压的无症状女性进行了Vabra（伯克利医疗设备公司，加利福尼亚州伯克利）抽吸筛查。
在患有糖尿病的女性中，发现了6.3%的子宫内膜癌前病变。这显著高于患有高血压女性中的发病率，后者为1.3%（P < 0.01）。
针对早期检测EC的定期大规模筛查项目应针对45岁及以上的无症状糖尿病女性。本研究并未表明类似筛查对患有高血压的女性有效。
