Geiger J M, Saurat J H
Department of Dermatology, Roche International Clinical Research Center, Strasbourg, France.
Dermatol Clin. 1993 Jan;11(1):117-29.
Nearly two decades after the advent of synthetic retinoids for the treatment of many severe and incapacitating dermatologic conditions, the usefulness of these drugs is not universally accepted. The safety profile is well established. Other than teratogenicity, which can be avoided if the recommended precautions for use are followed, serious or unexpected adverse reactions rarely occur. This article concisely addresses some questions about etretinate and acitretin therapy that are most pertinent for the dermatologist.
在合成维甲酸用于治疗多种严重且使人衰弱的皮肤病将近二十年之后，这些药物的效用并未得到普遍认可。其安全性已得到充分证实。除了致畸性（如果遵循推荐的使用预防措施即可避免）外，严重或意外的不良反应很少发生。本文简要探讨了一些与皮肤科医生最为相关的关于依曲替酯和阿维A治疗的问题。
