Bleiker T O, Bourke J F, Graham-Brown R A, Hutchinson P E
Department of Dermatology, Leicester Royal Infirmary, U.K.
Br J Dermatol. 1997 Mar;136(3):368-70.
Acitretin (Ro 10-1670, Neotigason), a second-generation monoaromatic retinoid, is the main acid derivative and active metabolite of etretinate (Ro 10-9359, Tigason). Three patients who were unresponsive to treatment with acitretin but who responded to etretinate are reported. Twenty-nine patients in the U.K. are currently receiving etretinate on a named-patient basis. Possible explanations for the functional discrepancy between the two drugs are discussed.
阿维A（Ro 10-1670，商品名：新银屑灵），一种第二代单芳香维甲酸，是依曲替酯（Ro 10-9359，商品名：银屑灵）的主要酸衍生物和活性代谢产物。本文报告了3例对阿维A治疗无反应但对依曲替酯有反应的患者。目前在英国有29名患者正在以指定患者的方式接受依曲替酯治疗。文中讨论了这两种药物功能差异的可能原因。
