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Autoantibodies directed against different classes of Fc gamma R are found in sera of autoimmune patients.

作者信息

Boros P, Muryoi T, Spiera H, Bona C, Unkeless J C

机构信息

Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029.

出版信息

J Immunol. 1993 Mar 1;150(5):2018-24.

PMID:8436832
Abstract

Serum samples from 147 patients with different systemic autoimmune diseases (SLE, Sjögren's syndrome, and progressive systemic sclerosis) were tested for anti-Fc gamma R activity using mouse rFc gamma RII in an ELISA. High reactivity compared to normal individuals was found for patients with all three diseases. The anti-Fc gamma R antibody was purified from several serum samples by affinity chromatography on a Sepharose column coupled with denatured, murine rFc gamma RII. Both IgM and IgG antibodies were found. To analyze the specificity of the affinity-purified autoantibody, cells (human neutrophils, IFN-gamma-stimulated neutrophils, monocytes, and the THP-1 monocytic cell line) that express different combinations of Fc gamma R (CD64, CD32, CD16) were stained with the affinity purified Ig. Ig directed against all three types of Fc gamma R were found. The results may reflect on the role of Fc gamma R-specific antibodies in the pathology of autoimmune diseases.

摘要

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