Pescatori E S, Calabro A, Artibani W, Pagano F, Triban C, Italiano G
Institute of Urology, University of Padova, Italy.
J Urol. 1993 Mar;149(3):627-32. doi: 10.1016/s0022-5347(17)36168-2.
An animal model using the spinal rat was characterized. Electrical stimulation of the dorsal nerve of the penis elicited reflex tonic erections of the penile body and reflex bulbospongiosus muscle activity, flips and ejaculations. The tonic erections of the penile body are independent from contractions of the bulbospongiosus muscle and appear to be the result of a neurovascular process. Our observations suggest that reflex bulbospongiosus muscle activity, flips and ejaculations are a single complex reflex response, which we define as reflex ejaculatory response. Two parameters predicted the occurrence and type of reflex response. The visualization of bulbospongiosus muscle activity during surgical isolation of the dorsal nerve of the penis was sufficient to anticipate the elicitability of reflex ejaculatory responses. The latter, together with a systemic systolic pressure > or = 73 mmHg., warranted the elicitability of reflex tonic erections. The similarities found in the physiology of rat tonic penile body erections and of human erections make this model promising for further elucidation of sexual function. Moreover, the present model may prove useful for the investigation of neurogenic erectile dysfunction, and of neurogenic ejaculatory disorders.
一种使用脊髓大鼠的动物模型得到了表征。对阴茎背神经进行电刺激可引发阴茎体的反射性强直性勃起、反射性球海绵体肌活动、抽动和射精。阴茎体的强直性勃起独立于球海绵体肌的收缩，似乎是神经血管过程的结果。我们的观察结果表明，反射性球海绵体肌活动、抽动和射精是一种单一的复杂反射反应，我们将其定义为反射性射精反应。两个参数可预测反射反应的发生和类型。在手术分离阴茎背神经期间可视化球海绵体肌活动足以预测反射性射精反应的可诱发情况。后者，再加上全身收缩压≥73 mmHg，保证了反射性强直性勃起的可诱发情况。在大鼠阴茎体强直性勃起和人类勃起的生理学中发现的相似性使得该模型有望进一步阐明性功能。此外，目前的模型可能被证明对研究神经源性勃起功能障碍和神经源性射精障碍有用。
