Gur E, Waner T
Life Science Research Israel, Ness Ziona.
Lab Anim. 1993 Jan;27(1):65-72. doi: 10.1258/002367793781082368.
The variability of organ weight data in a series of 5 control groups of Sprague-Dawley rats was studied. Differences in body weight and organ weight data were detected between the studies. Attempts to reduce the variability of organ weights by using analysis of covariance or organ to brain weight ratios were only partially successful. Factors which may influence animals under controlled conditions and result in variability between studies are discussed. It is concluded that caution is needed when considering the use of organ weight background data as a means of comparison. The findings are in agreement with other fields of study in toxicological testing, and emphasize the importance of using a concurrent control for the purpose of comparison of data.
对一系列5个Sprague-Dawley大鼠对照组的器官重量数据变异性进行了研究。在各项研究之间检测到了体重和器官重量数据的差异。试图通过协方差分析或器官与脑重量比来降低器官重量的变异性仅取得了部分成功。讨论了在受控条件下可能影响动物并导致研究之间变异性的因素。得出的结论是，在考虑将器官重量背景数据用作比较手段时需要谨慎。这些发现与毒理学测试的其他研究领域一致，并强调了使用同期对照进行数据比较的重要性。
