Piao Ying, Liu Yunen, Xie Xiaodong
Oncology Department, Cancer Treatment Center, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenhe District, Shenyang City, 110001, P. R. China.
J Toxicol Pathol. 2013 Mar;26(1):29-34. doi: 10.1293/tox.26.29. Epub 2013 Apr 22.
Organ weight is one of the most sensitive drug toxicity indicators, and its changes often precede morphological changes. So far, no background data about organ weight and its coefficient in SD rats at different weeks of age have been reported in China. The aim of this study was to summarize and analyze the change trends of organ weight and organ weight coefficients in SD rats at different weeks of age. The absolute of the weights of the brain, spleen, heart, lungs, liver, kidneys, adrenal glands and testes were increased in male SD rats from 13 to 78 weeks, and the weights of the brain, heart, lungs, liver, kidneys and especially the testes were decreased from 78 to 104 weeks. On the other hand, the absolute weight of the adrenal glands showed an increasing trend from 13 to 104 weeks. The absolute weight of the brain, spleen, heart, lungs, liver, kidneys, adrenal glands and ovaries showed an increasing trend from 13 to 104 weeks. A significant increase was observed in adrenal gland and ovary weights, whereas no obvious change trends were observed for the other organ weights mentioned above. It was surprising that the absolute of weight of the adrenal glands and organ-to-brain and organ-to-body weight ratios in female rats were significantly higher than those in males from 13 to 104 weeks. This study was the first to establish background data for organ weights in SD rats at different weeks of age and their reference ranges in line with the experimental animal status in China and to summarize their summarized their changes trend.
脏器重量是最敏感的药物毒性指标之一，其变化往往先于形态学改变。目前，国内尚未见关于不同周龄SD大鼠脏器重量及其系数的背景数据报道。本研究旨在总结分析不同周龄SD大鼠脏器重量及脏器重量系数的变化趋势。雄性SD大鼠从13周龄至78周龄，脑、脾、心、肺、肝、肾、肾上腺和睾丸的绝对重量增加，从78周龄至104周龄，脑、心、肺、肝、肾尤其是睾丸的重量下降。另一方面，肾上腺的绝对重量从13周龄至104周龄呈增加趋势。雌性大鼠从13周龄至104周龄，脑、脾、心、肺、肝、肾、肾上腺和卵巢的绝对重量呈增加趋势。肾上腺和卵巢重量显著增加，而上述其他脏器重量未观察到明显变化趋势。令人惊讶的是，13周龄至104周龄雌性大鼠肾上腺的绝对重量以及脏器与脑和脏器与体重的比值均显著高于雄性大鼠。本研究首次建立了符合我国实验动物状况的不同周龄SD大鼠脏器重量背景数据及其参考范围，并总结了其变化趋势。
