多发性脊髓脑膜瘤：一例无神经纤维瘤病或明确染色体异常情况下出现47个不同病灶的病例。

Multiple spinal meningiomas: a case of 47 distinct lesions in the absence of neurofibromatosis or identified chromosomal abnormality.

作者信息

Chaparro M J, Young R F, Smith M, Shen V, Choi B H

机构信息

Department of Surgery, College of Medicine, University of California, Irvine.

出版信息

Neurosurgery. 1993 Feb;32(2):298-301; discussion 301-2. doi: 10.1227/00006123-199302000-00021.

DOI:10.1227/00006123-199302000-00021

PMID:8437669

Abstract

The authors present a unique case of multiple spinal meningiomas with the late development of intracranial lesions. The patient had 47 distinctly separate, yet histologically identical, lesions excised, with many others noted at the time of surgery and by radiographic studies. He was evaluated for neurofibromatosis and was found to have neither Type I nor Type II. Genetic analysis, including restriction fragment length polymorphism analysis, was performed and detected no abnormalities.

摘要

作者报告了一例独特的多发性脊髓脑膜瘤病例，颅内病变出现较晚。该患者切除了47个明显独立但组织学上相同的病变，手术时及影像学检查还发现了许多其他病变。对其进行了神经纤维瘤病评估，发现既没有I型也没有II型。进行了包括限制性片段长度多态性分析在内的基因分析，未检测到异常。