Sutherland R, Vincent P C, Raik E, Burgess K
Br Med J. 1977 Mar 5;1(6061):605-7. doi: 10.1136/bmj.1.6061.605.
In a case of quinine-induced agranulocytosis marrow culture studies confirmed the inhibitory effect on the patient's cells of equivalent therapeutic plasma concentrations of quinine. Similar concentrations had no effect on normal marrow cells. Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells. The results encourage the use of in-vitro bone marrow cultures for identifying drugs responsible for agranulocytosis.
在一例奎宁诱导的粒细胞缺乏症病例中，骨髓培养研究证实，与治疗浓度相当的血浆奎宁对患者细胞具有抑制作用。相似浓度对正常骨髓细胞无影响。奎宁的立体异构体奎尼丁对患者细胞和正常细胞均无影响。这些结果支持利用体外骨髓培养来鉴定导致粒细胞缺乏症的药物。
