阿莫地喹诱导的粒细胞缺乏症：抗疟药对骨髓集落生长的抑制作用。
Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents.
作者信息
Rhodes E G, Ball J, Franklin I M
出版信息
Br Med J (Clin Res Ed). 1986 Mar 15;292(6522):717-8. doi: 10.1136/bmj.292.6522.717.
Abstract
Bone marrow was cultured in vitro for colonies of granulocytes and macrophages five months after a patient had recovered from amodiaquine induced agranulocytosis. The addition of amodiaquine, chloroquine, and sulfadoxine to the culture was followed by a dose dependent inhibition of colony growth in the patient's marrow but not in normal control bone marrow. Colony growth was, however, unaffected by proguanil, pyrimethamine, and quinine. These findings show that in vitro marrow culture may have important predictive value in some cases of drug induced agranulocytosis.
摘要
一名患者从阿莫地喹诱发的粒细胞缺乏症康复五个月后，其骨髓在体外培养以形成粒细胞和巨噬细胞集落。在培养物中添加阿莫地喹、氯喹和周效磺胺后，患者骨髓中的集落生长受到剂量依赖性抑制，但正常对照骨髓中未受影响。然而，氯胍、乙胺嘧啶和奎宁对集落生长没有影响。这些发现表明，体外骨髓培养在某些药物诱发的粒细胞缺乏症病例中可能具有重要的预测价值。
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本文引用的文献
1
Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro.阿莫地喹诱导的粒细胞缺乏症：阿莫地喹在体外骨髓培养中的毒性作用。
Br Med J. 1973 Feb 24;1(5851):458-60. doi: 10.1136/bmj.1.5851.458.
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