Gainsborough N, Maskrey V L, Nelson M L, Keating J, Sherwood R A, Jackson S H, Swift C G
Department of Health Care of the Elderly, King's College School of Medicine and Dentistry, Denmark Hill, London.
Age Ageing. 1993 Jan;22(1):37-40. doi: 10.1093/ageing/22.1.37.
Gastric emptying is important as a rate-limiting step in the absorption of orally administered drugs. Paracetamol absorption kinetics were used to compare gastric emptying in 19 fit elderly and 19 fit young volunteers. The results showed no significant difference in any of the derived parameters (t1/2abs, tlag and tmax) between the two groups. These results suggest that ageing does not impair this rate-limiting step in drug absorption.
胃排空作为口服药物吸收的限速步骤至关重要。对19名健康老年志愿者和19名健康年轻志愿者，利用对乙酰氨基酚吸收动力学来比较胃排空情况。结果显示，两组之间的任何衍生参数（吸收半衰期、延迟时间和达峰时间）均无显著差异。这些结果表明，衰老不会损害药物吸收中的这一限速步骤。
