肽酶的进化家族。
Evolutionary families of peptidases.
作者信息
Rawlings N D, Barrett A J
机构信息
Department of Biochemistry, Strangeways Research Laboratory, Worts Causeway, Cambridge, U.K.
出版信息
Biochem J. 1993 Feb 15;290 ( Pt 1)(Pt 1):205-18. doi: 10.1042/bj2900205.
Abstract
The available amino acid sequences of peptidases have been examined, and the enzymes have been allocated to evolutionary families. Some of the families can be grouped together in 'clans' that show signs of distant relationship, but nevertheless, it appears that there may be as many as 60 evolutionary lines of peptidases with separate origins. Some of these contain members with quite diverse peptidase activities, and yet there are some striking examples of convergence. We suggest that the classification by families could be used as an extension of the current classification by catalytic type.
摘要
已对肽酶的现有氨基酸序列进行了研究，并将这些酶归入了进化家族。其中一些家族可归为“族”，这些“族”显示出远亲关系的迹象，但即便如此，似乎可能有多达60条具有不同起源的肽酶进化谱系。其中一些谱系包含具有相当多样肽酶活性的成员，不过也有一些引人注目的趋同实例。我们建议按家族进行的分类可作为当前按催化类型分类的扩展。
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