大蒜及其对人类癌症预防的意义：批判性观点。
Garlic and its significance for the prevention of cancer in humans: a critical view.
作者信息
Dorant E, van den Brandt P A, Goldbohm R A, Hermus R J, Sturmans F
机构信息
Department of Epidemiology, University of Limburg, Maastricht.
出版信息
Br J Cancer. 1993 Mar;67(3):424-9. doi: 10.1038/bjc.1993.82.
Recently published results of epidemiologic case-control studies in China and Italy on gastric carcinoma in relation to diet suggest that consuming garlic may reduce the risk of gastric cancer. Chemical constituents of garlic have been tested for their inhibiting effect on carcinogenesis, using in vitro and in vivo models. In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs. In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans. It is concluded that evidence from laboratory experiments and epidemiologic studies is presently not conclusive as to the preventive activity of garlic. However, the available evidence warrants further research into the possible role of garlic in the prevention of cancer in humans.
中国和意大利最近发表的关于饮食与胃癌关系的流行病学病例对照研究结果表明，食用大蒜可能降低患胃癌的风险。已利用体外和体内模型测试了大蒜的化学成分对致癌作用的抑制效果。在大多数实验中，使用新鲜大蒜提取物、大蒜化合物或合成制备的类似物确定了对肿瘤生长的抑制作用。在这篇综述中，讨论了实验的优缺点，并对结果进行了评估，以评估大蒜或大蒜化合物对预防人类癌症的潜在意义。得出的结论是，目前关于大蒜预防活性的实验室实验和流行病学研究证据尚无定论。然而，现有证据值得进一步研究大蒜在预防人类癌症方面的可能作用。
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