Bhavana Sujana Mulk, Lakshmi Chintamaneni Raja
Department of Oral Medicine and Radiology, Drs Sudha & Nageswararao Siddhartha, Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhrapradesh, India.
Adv Pharm Bull. 2014 Oct;4(Suppl 1):413-20. doi: 10.5681/apb.2014.061. Epub 2014 Aug 25.
The aim of this article is to emphasize and focus on the preclinical and clinical update on phytochemicals and their role in prevention of oral carcinogenesis. Accordingly, the literature search was made following database: Embase, Medline, Science Citation index, NIH public access, pubmed and Cochrane Database of systematic reviews. Several internet websites were also searched to access publications from major phytochemical research sites and relevant information was obtained with regards to each plant chemical. The authors also spotted different list servers through wignet.com, Stanford cancer research etc: The data base search was made from the inception to 1988 and updated till 2013. A systematic method was obtained for literature search and data collection was critiqued. 60 articles were searched, among which there were only 6 systematic reviews on phytochemicals regarding oral carcinogenesis. Additional articles were obtained on phytochemicals and their mechanism of action in other cancers, which were regarded as background material. The studies done by various authors on each phytochemical has been briefly emphasized.
本文旨在强调并聚焦于植物化学物质的临床前和临床进展及其在预防口腔癌发生中的作用。相应地，按照以下数据库进行了文献检索：Embase、Medline、科学引文索引、美国国立医学图书馆公共获取数据库、PubMed以及Cochrane系统评价数据库。还搜索了多个互联网网站，以获取主要植物化学物质研究网站的出版物，并获得了关于每种植物化学物质的相关信息。作者还通过wignet.com、斯坦福癌症研究等发现了不同的邮件列表服务器：数据库检索从1988年开始，更新至2013年。获得了一种系统的文献检索方法，并对数据收集进行了评判。共检索到60篇文章，其中关于植物化学物质与口腔癌发生的系统评价仅有6篇。还获得了关于植物化学物质及其在其他癌症中的作用机制的额外文章，这些文章被视为背景材料。简要强调了各位作者对每种植物化学物质所做的研究。
