Grzegorzewska A E, Moore H L, Chen T W, Nolph K D
Department of Medicine, University of Missouri Health Sciences Center, Columbia 65212.
ASAIO J. 1993 Jan-Mar;39(1):66-70.
Peritoneal transfer parameters were estimated in rats (n = 24) while maximal net ultrafiltration rate (nUFR) was achieved with 15% dextrose dialysis solution (1,153 mOsm/kg) and compared with those obtained with 0.37% dextrose solution (301 mOsm/kg). Experiments were carried out with dialysis solutions of pH approximately 6.5 and approximately 7.6, respectively, for 15% dextrose dialysis solution and 0.37% dextrose solution. Increases in both convective and diffusive transfer resulted in more than 70% greater peritoneal clearances of urea, potassium, and phosphate with hyperosmotic solutions at both pH values. Protein removal was increased only with a hyperosmotic solution of pH approximately 6.5 compared with isosmotic conditions at the same pH. Results support the hypothesis that increased peritoneal transfer parameters under hyperosmotic conditions depend not only upon enhanced convection but also on factors promoting diffusive transfer.
在大鼠（n = 24）中估计腹膜转运参数，同时使用15%葡萄糖透析液（1,153 mOsm/kg）达到最大净超滤率（nUFR），并与使用0.37%葡萄糖溶液（301 mOsm/kg）获得的参数进行比较。分别使用pH约为6.5和约7.6的透析液对15%葡萄糖透析液和0.37%葡萄糖溶液进行实验。在两种pH值下，对流和扩散转运的增加均导致高渗溶液使尿素、钾和磷酸盐的腹膜清除率提高70%以上。与相同pH值的等渗条件相比，仅在pH约为6.5的高渗溶液中蛋白质清除率增加。结果支持以下假设：高渗条件下腹膜转运参数的增加不仅取决于对流增强，还取决于促进扩散转运的因素。
