Isoniazid-associated psychosis: case report and review of the literature.

OBJECTIVE

To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect.

DATA SOURCES

Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information.

STUDY SELECTION

All case reports describing isoniazid-associated psychosis were reviewed.

DATA EXTRACTION

Studies were evaluated for the use of isoniazid, symptoms of psychosis, onset of symptoms, and dosage of isoniazid.

DATA SYNTHESIS

The case report is compared with others reported in the literature. The incidence of isoniazid-associated psychosis is rare.

CONCLUSIONS

The mechanism of isoniazid-associated psychosis is uncertain. It appears that isoniazid was associated with the psychosis evident in our patient and in the cases reviewed.