Pallone K A, Goldman M P, Fuller M A
Collaborative Clinical Research, Inc., URC II, Cleveland, OH 44106.
Ann Pharmacother. 1993 Feb;27(2):167-70. doi: 10.1177/106002809302700205.
To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect.
Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information.
All case reports describing isoniazid-associated psychosis were reviewed.
Studies were evaluated for the use of isoniazid, symptoms of psychosis, onset of symptoms, and dosage of isoniazid.
The case report is compared with others reported in the literature. The incidence of isoniazid-associated psychosis is rare.
The mechanism of isoniazid-associated psychosis is uncertain. It appears that isoniazid was associated with the psychosis evident in our patient and in the cases reviewed.
描述一例异烟肼相关精神病病例，并回顾这种不良反应的发生率。
有关该患者的信息取自病历。对1950年至1992年发表的英文文献进行了MEDLINE检索，并手动检索了《医学索引》以获取最新信息。
对所有描述异烟肼相关精神病的病例报告进行了回顾。
对各项研究评估了异烟肼的使用情况、精神病症状、症状发作情况以及异烟肼的剂量。
将该病例报告与文献中报道的其他病例进行了比较。异烟肼相关精神病的发生率很低。
异烟肼相关精神病的机制尚不确定。异烟肼似乎与我们的患者及所回顾病例中出现的精神病有关。
