Baskin D S, Simpson R K, Browning J L, Dudley A W, Rothenberg F, Bogue L
Department of Surgery, Veterans Affairs Medical Center, Houston, Texas.
J Spinal Disord. 1993 Feb;6(1):38-43.
The effect of long-term continuous subcutaneous infusion of naloxone on blunt spinal cord injury in the rat was assessed using four tests of neurological function, seven histological categories, and two electrophysiological measures. All four neurological function tests showed a trend toward improvement in naloxone-treated animals: the degree of improvement was statistically significant in two of the four categories. A significant reduction in myelin sheath edema was found in the naloxone-treated animals. Although there was a decrease in corticomotor-evoked potentials complexity following injury, there was no significant difference in naloxone-treated animals. Somatosensory-evoked potentials were significantly increased in amplitude and latency in naloxone-treated animals. This increase was most apparent at 60 min: no difference was found by 3 weeks postinjury. These results confirm earlier reports that naloxone can ameliorate the functional neurological deficits of spinal cord injury. Naloxone also produces alterations in the somatosensory-evoked responses in the early phase of treatment and significantly reduces myelin sheath edema.
使用四项神经功能测试、七种类别组织学和两种电生理测量方法，评估了长期连续皮下注射纳洛酮对大鼠钝性脊髓损伤的影响。所有四项神经功能测试均显示，接受纳洛酮治疗的动物有改善趋势：在四个类别中的两个类别中，改善程度具有统计学意义。在接受纳洛酮治疗的动物中，发现髓鞘水肿明显减轻。虽然损伤后皮质运动诱发电位的复杂性有所降低，但在接受纳洛酮治疗的动物中没有显著差异。在接受纳洛酮治疗的动物中，体感诱发电位的幅度和潜伏期显著增加。这种增加在60分钟时最为明显：在损伤后3周时未发现差异。这些结果证实了早期的报道，即纳洛酮可以改善脊髓损伤的功能性神经缺陷。纳洛酮还会在治疗早期引起体感诱发电反应的改变，并显著减轻髓鞘水肿。
