通过氚和荧光原位杂交技术将人类甲状腺过氧化物酶基因（TPO）区域亚定位到染色体2p25→p24。

Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25-->p24.

作者信息

Barnett P S, Jones T A, McGregor A M, Banga J P, Sheer D

机构信息

Department of Medicine, King's College School of Medicine and Dentistry, London, UK.

出版信息

Cytogenet Cell Genet. 1993;62(4):188-9. doi: 10.1159/000133471.

DOI:10.1159/000133471

PMID:8440133

Abstract

Thyroid peroxidase (TPO), the enzyme responsible for thyroid hormone synthesis, is a key autoantigen in autoimmune thyroid disease. Based on the results of a study using both isotopic and nonisotopic in situ hybridization, we assign the gene coding for human TPO to chromosome region 2p25-->p24.

摘要

甲状腺过氧化物酶（TPO）是负责甲状腺激素合成的酶，是自身免疫性甲状腺疾病中的关键自身抗原。基于一项同时使用同位素和非同位素原位杂交的研究结果，我们将编码人TPO的基因定位于染色体区域2p25→p24。