Simon D, Knowles B B
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Cytogenet Cell Genet. 1993;62(4):211-3. doi: 10.1159/000133478.
Karyotypes of an embryonic stem cell line and normal bone marrow and peripheral blood cells from a transgenic mouse lineage, strain 83, exhibit a novel region of constitutive heterochromatin in the peri-telomeric region of chromosome 3. This heterochromatic region co-localizes with the integration site of the transgene, an 11-Mb tandem insertion of a plasmid containing human beta-globin gene sequences, and is inherited in Mendelian fashion. The significance of this finding is discussed, and a nomenclature for such newly acquired heterochromatic regions is suggested.
一种胚胎干细胞系以及来自83品系转基因小鼠谱系的正常骨髓和外周血细胞的核型显示，在3号染色体的端粒周围区域存在一个新的组成型异染色质区域。这个异染色质区域与转基因的整合位点共定位，该转基因是一个包含人类β-珠蛋白基因序列的质粒的11兆碱基串联插入，并且以孟德尔方式遗传。本文讨论了这一发现的意义，并提出了此类新获得的异染色质区域的命名法。
