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通过给予呋塞米预防接受顺二氨二氯铂（II）的大鼠发生肾衰竭。

Prevention of renal failure in rats receiving cis-diamminedichloroplatinum(II) by administration of furosemide.

作者信息

Ward J M, Grabin M E, Berlin E, Young D M

出版信息

Cancer Res. 1977 Apr;37(4):1238-40.

PMID:844049
Abstract

The clinicopathological signs of renal failure induced in rats by weekly i.v. administration of cis-diamminedichloroplatinum(II) were prevented by pretreatment with furosemide. Weight loss, anemia, and generalized toxic effects of the drug were not effected by furosemide.

摘要

每周静脉注射顺二氨二氯铂（II）诱导大鼠出现肾衰竭的临床病理体征可通过速尿预处理来预防。速尿对体重减轻、贫血以及该药物的全身毒性作用没有影响。

相似文献

1
Prevention of renal failure in rats receiving cis-diamminedichloroplatinum(II) by administration of furosemide.通过给予呋塞米预防接受顺二氨二氯铂（II）的大鼠发生肾衰竭。
Cancer Res. 1977 Apr;37(4):1238-40.
2
Modification of the renal toxicity of cis-dichlorodiammineplatinum(II) with furosemide in male F344 rats.呋塞米对雄性F344大鼠顺式二氯二氨铂（II）肾毒性的影响
Cancer Treat Rep. 1977 May-Jun;61(3):375-9.
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Protective effects of O-(beta-hydroxyethyl)-rutoside on cis-platinum-induced acute renal failure in the rat.O-（β-羟乙基）芦丁对顺铂诱导的大鼠急性肾衰竭的保护作用。
Lab Invest. 1986 Nov;55(5):557-63.
4
Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations.顺二氯二氨合铂（II）诱导的大鼠急性肾衰竭。结构与功能改变的相关性。
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Prevention of the initial oliguria of acute renal failure by the administration of frusemide.通过给予速尿预防急性肾衰竭初期少尿
Postgrad Med J. 1971 Apr;47:Suppl:7-10.
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Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria.顺铂诱导的肾毒性与大鼠肾线粒体中的氧化应激、氧化还原状态失衡、能量代谢受损和细胞凋亡有关。
Arch Toxicol. 2007 Jul;81(7):495-504. doi: 10.1007/s00204-006-0173-2. Epub 2007 Jan 11.
7
Cis-diamminedichloroplatinum (DDP) induced acute renal failure (ARF): attempts at amelioration.顺二氯二氨合铂（DDP）诱导的急性肾衰竭（ARF）：改善尝试。
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[Effect of furosemide and aminophylline in experimental acute post-ischemic renal failure].[速尿和氨茶碱对实验性急性缺血后肾衰竭的影响]
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Nephrotoxic potential of cis-diamminedichloroplatinum and four analogs in male Fischer 344 rats.顺二氯二氨铂及其四种类似物对雄性Fischer 344大鼠的肾毒性潜力。
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Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure.大剂量呋塞米与小剂量多巴胺治疗难治性充血性心力衰竭时的毒性增加。
Clin Pharmacol Ther. 1997 Aug;62(2):187-93. doi: 10.1016/S0009-9236(97)90067-9.

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3
Effects of the diuretics mannitol or acetazolamide on nephrotoxicity and physiological disposition of cisplatin in rats.
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Attenuation of cisplatinum-induced nephrotoxicity in the rat by high salt diet, furosemide and acetazolamide.
Naunyn Schmiedebergs Arch Pharmacol. 1985 Apr;329(2):201-5. doi: 10.1007/BF00501213.
5
Influence of frusemide on cis-dichlorodiammineplatinum (II) pharmaco-kinetics.速尿对顺二氯二氨铂（II）药代动力学的影响。
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6
Sodium thiosulfate fails to increase the therapeutic index of intravenously administered cis-diamminedichloroplatinum (II) in mice bearing murine and human tumors.
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Evolution of high-dose cisplatin.
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