局部应用苯并（a）芘、苯并（a）芘二醇环氧化物及其他代谢产物后出现的表皮增生。
Epidermal hyperplasia after topical application of benzo (a) pyrene, benzo (a) pyrene diol epoxides, and other metabolites.
作者信息
Bresnick E, McDonald T F, Yagi H, Jerina D M, Levin W, Wood A W, Conney A H
出版信息
Cancer Res. 1977 Apr;37(4):984-90.
The effects of benzo(a)pyrene (BP) and 22 derivatives upon the number of nuclei per unit length of epidermis, the number of cell layers of epidermis, and the thickness of the epidermal layer were studied. Several derivatives of BP induced changes in epidermal morphology that are typical of those produced by various agents that promote skin tumorigenesis after application of an initiator. The most potent compounds tested were the BP diol epoxides, (+/-)-7beta,8alpha-dihydroxy-9beta, 10beta-epoxy-7,8,9,10-tetrahydrobenzo-(a)pyrene (diol epoxide 1) and (+/-)-7beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (diol epoxide 2). These derivatives were followed in activity by 9-hydroxybenzo(a)pyrene, 2-hydroxybenzo(a)pyrene, and by 9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene. The possible implications of these results with regard to the carcinogenicity of BP on mouse skin are discussed.
研究了苯并(a)芘（BP）及其22种衍生物对表皮单位长度内核的数量、表皮细胞层数以及表皮层厚度的影响。BP的几种衍生物引起了表皮形态的变化，这些变化是在应用引发剂后促进皮肤肿瘤发生的各种试剂所产生的典型变化。所测试的最有效的化合物是BP二醇环氧化物，(±)-7β,8α-二羟基-9β,10β-环氧-7,8,9,10-四氢苯并(a)芘（二醇环氧化物1）和(±)-7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并(a)芘（二醇环氧化物2）。这些衍生物之后的活性依次为9-羟基苯并(a)芘、2-羟基苯并(a)芘以及9,10-环氧-7,8,9,10-四氢苯并(a)芘。讨论了这些结果对BP在小鼠皮肤上致癌性的可能影响。
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