Castañeda-Hernández G, Hoyo-Vadillo C, Palma-Aguirre J A, Flores-Murrieta F J
Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Mexico, D.F., Mexico.
J Clin Pharmacol. 1993 Feb;33(2):140-5. doi: 10.1002/j.1552-4604.1993.tb03934.x.
Nifedipine disposition varies among populations. Reports on oral nifedipine pharmacokinetics show that peak plasma levels and AUC values are higher in Mexican and Japanese than in European and North American subjects. Increased nifedipine bioavailability in the nonwhite populations is likely due to nutritional habits. Certain flavonoids that inhibit the first-pass metabolism of dihydropyridines are present in the diets of both Mexican and Japanese. Differences in phenotypes may play a role in interethnic variability.
硝苯地平在不同人群中的处置情况有所不同。关于口服硝苯地平药代动力学的报告显示，墨西哥人和日本人的血浆峰值水平和AUC值高于欧洲人和北美受试者。非白人人群中硝苯地平生物利用度的增加可能归因于饮食习惯。墨西哥人和日本人的饮食中都含有某些抑制二氢吡啶首过代谢的黄酮类化合物。表型差异可能在种族间变异性中起作用。
