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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Renwick A G, Robertson D R, Macklin B, Challenor V, Waller D G, George C F

Clinical Pharmacology Group, University of Southampton.

Br J Clin Pharmacol. 1988 Jun;25(6):701-8. doi: 10.1111/j.1365-2125.1988.tb05256.x.

The pharmacokinetics and metabolism of nifedipine have been studied in a population of 59 young male volunteers following administration of a 10 mg capsule. 2. The area under the plasma concentration-time curves (AUC) for nifedipine demonstrated a skewed but not a bimodal distribution (mean 154 ng ml-1 h; range 54-306 ng ml-1h). 3. Calculation of the ratio of the AUC of nifedipine to the AUC of its nitropyridine metabolite did not separate those individuals with high AUC values of nifedipine from the remainder of the population. 4. Similarly there was no evidence for bimodality in the excretion of the major urinary metabolite. Those subjects with high plasma AUC values for nifedipine excreted similar amounts to the remainder of the population. 5. In contrast to a previous study using a 20 mg oral dose, there was no evidence of polymorphism in the pharmacokinetics or metabolism of nifedipine following a single 10 mg oral dose.

在59名年轻男性志愿者群体中，口服10毫克胶囊后对硝苯地平的药代动力学和代谢情况进行了研究。2. 硝苯地平的血浆浓度-时间曲线下面积（AUC）呈偏态分布而非双峰分布（均值为154纳克·毫升⁻¹·小时；范围为54 - 306纳克·毫升⁻¹·小时）。3. 计算硝苯地平AUC与其硝基吡啶代谢产物AUC的比值，未能将硝苯地平AUC值高的个体与其余人群区分开来。4. 同样，主要尿代谢产物的排泄也没有双峰现象的证据。硝苯地平血浆AUC值高的受试者排泄量与其余人群相似。5. 与之前使用20毫克口服剂量的研究不同，单次口服10毫克硝苯地平后，其药代动力学或代谢过程中没有多态性的证据。

Renwick A G, Robertson D R, Macklin B, Challenor V, Waller D G, George C F

Clinical Pharmacology Group, University of Southampton.

Br J Clin Pharmacol. 1988 Jun;25(6):701-8. doi: 10.1111/j.1365-2125.1988.tb05256.x.

The pharmacokinetics and metabolism of nifedipine have been studied in a population of 59 young male volunteers following administration of a 10 mg capsule. 2. The area under the plasma concentration-time curves (AUC) for nifedipine demonstrated a skewed but not a bimodal distribution (mean 154 ng ml-1 h; range 54-306 ng ml-1h). 3. Calculation of the ratio of the AUC of nifedipine to the AUC of its nitropyridine metabolite did not separate those individuals with high AUC values of nifedipine from the remainder of the population. 4. Similarly there was no evidence for bimodality in the excretion of the major urinary metabolite. Those subjects with high plasma AUC values for nifedipine excreted similar amounts to the remainder of the population. 5. In contrast to a previous study using a 20 mg oral dose, there was no evidence of polymorphism in the pharmacokinetics or metabolism of nifedipine following a single 10 mg oral dose.

在59名年轻男性志愿者群体中，口服10毫克胶囊后对硝苯地平的药代动力学和代谢情况进行了研究。2. 硝苯地平的血浆浓度-时间曲线下面积（AUC）呈偏态分布而非双峰分布（均值为154纳克·毫升⁻¹·小时；范围为54 - 306纳克·毫升⁻¹·小时）。3. 计算硝苯地平AUC与其硝基吡啶代谢产物AUC的比值，未能将硝苯地平AUC值高的个体与其余人群区分开来。4. 同样，主要尿代谢产物的排泄也没有双峰现象的证据。硝苯地平血浆AUC值高的受试者排泄量与其余人群相似。5. 与之前使用20毫克口服剂量的研究不同，单次口服10毫克硝苯地平后，其药代动力学或代谢过程中没有多态性的证据。