Soravia C, Romand J A, Herrmann M, Chevrolet J C, Ricou B, Suter P M
Department of Anaesthesia, University Hospital of Geneva, Switzerland.
Intensive Care Med. 1993;19(1):53-6. doi: 10.1007/BF01709279.
During the last two decades, severe group A beta-haemolytic streptococcal infections have been defined as the "toxic strep syndrome", and have been reported not only in immunocompromised or elderly people, but also occasionally in previously healthy patients. We describe 4 patients presenting with the toxic strep syndrome, requiring surgery and intensive care, and briefly review the related literature. Fatigue, localized pain and other nonspecific symptoms were associated with the onset of the disease, followed by septic shock with multiple organ failure. Early diagnosis and surgical intervention, if necessary, are mandatory. Subsequently, appropriate supportive treatment of vital organ dysfunction and penicillin as the antibiotic of choice represent the cornerstones of the management of this syndrome.
在过去二十年中，严重的A组β溶血性链球菌感染被定义为“中毒性链球菌综合征”，不仅在免疫功能低下或老年人中有所报道，偶尔也在先前健康的患者中出现。我们描述了4例患有中毒性链球菌综合征的患者，他们需要手术和重症监护，并简要回顾相关文献。疲劳、局部疼痛和其他非特异性症状与疾病发作有关，随后出现伴有多器官功能衰竭的感染性休克。早期诊断以及必要时的手术干预是必不可少的。随后，对重要器官功能障碍进行适当的支持治疗以及选用青霉素作为抗生素是该综合征治疗的基石。
