Sparks D L, Liu H, Scheff S W, Coyne C M, Hunsaker J C
Sanders-Brown Center on Aging, U.K.M.C., Lexington 40536-0230.
J Neuropathol Exp Neurol. 1993 Mar;52(2):135-42. doi: 10.1097/00005072-199303000-00006.
One of the hallmarks of Alzheimer's disease is the presence of argyrophilic plaques (arg-P) accompanying dementia and other forms of cognitive alterations. In the present investigation 195 non-demented, cognitively normal patients were grouped according to the presence or absence of critical coronary artery disease (cCAD), defined as a 75% or greater stenosis of one of the epicardial arteries. None of the subjects had significant cerebral vascular disease. The parahippocampal gyrus (PHG) and frontal pole were analyzed for the presence of arg-P, A4 deposition, ALZ-50 immunoreactive (IR) neurons and neuropil threads (NT). Individuals with cCAD have a significantly greater incidence of plaques than non-heart disease (non-HD) subjects. Every cCAD subject had ALZ-50 IR neurons in the PHG and a greater incidence of NT as compared to the non-HD subjects. Every subject with plaques also had IR neurons and NT in the PHG. Based on the presumption that early neurodegeneration labeled by ALZ-50 antibody and amyloid deposition are in some way linked, then the sequence of plaque formation is initiated by the presence of ALZ-50 IR neurons followed in order by NT, A4 deposition and diffuse form arg-P.
阿尔茨海默病的一个标志性特征是嗜银斑（arg-P）的出现，同时伴有痴呆和其他形式的认知改变。在本研究中，195名无痴呆、认知正常的患者根据是否存在严重冠状动脉疾病（cCAD）进行分组，cCAD定义为一支心外膜动脉狭窄75%或更高。所有受试者均无明显脑血管疾病。分析海马旁回（PHG）和额极中嗜银斑、A4沉积、ALZ-50免疫反应性（IR）神经元和神经原纤维（NT）的存在情况。患有cCAD的个体中斑块的发生率显著高于非心脏病（非HD）受试者。与非HD受试者相比，每个患有cCAD的受试者在PHG中都有ALZ-50 IR神经元，且NT的发生率更高。每个有斑块的受试者在PHG中也有IR神经元和NT。基于ALZ-50抗体标记的早期神经退行性变与淀粉样蛋白沉积在某种程度上相关的假设，那么斑块形成的顺序是由ALZ-50 IR神经元的存在引发，随后依次是NT、A4沉积和弥漫性嗜银斑。
